Dr. Milana Frenkel-Morgenstern

Liquid Biopsy Platform for Early Diagnostics of Brain Tumors

The Azrieli Faculty of Medicine


Dr. Frenkel-Morgenstern is a systems biologist with a coherent career leading to excellence in extracting the maximal capabilities in a wide variety of molecular & computational tools. She remained focus on creative improvements in the interphase of large scale data and personalized diagnostics. Her background knowledge is in computational and molecular biology, cancer genomics and transcriptomics. Currently, she has integrated two labs under her supervision: Computational Biology lab (equipped with 4 Dell ultra-large memory servers and 1PetaByte storage) and a wet Molecular Biology & Cancer Genomics laboratory. Her team has the skills to bridge the gap between hundreds of thousands of parameters studied in the laboratory or by computational biology and deliver reliable platforms answering specific clinical questions that remain unmet. Her labs are utilizing various sequencing methods to uncover unique genomics, epigenetics and metagenomics characteristics in vitro as well as analysing tissue and blood samples from cancer patients for Personalized Medicine approaches. During her first postdoctoral study at Prof. Uri Alon's lab, Weizmann Institute of Science, she gained a substantial expertise in Systems Biology. During her second postdoc at Prof. Alfonso Valencia's lab, Spanish National Cancer Research Centre (CNIO), she studied Cancer Genomics and chimeric transcripts in different cancer types. She solved the problems in genomics and cancer biology using theoretical models matched with empirical experimentation. She is particularly interested to study such naturally occurring phenomenon as trans-splicing and fusion proteins in cancers, as well as regulation of protein translation by transfer-RNAs during the cell-cycle, chimeric RNA transcripts and proteins, changes in protein-protein interaction networks by fusion proteins, single cell sequencing and cell-to-cell variability, personalized medicine and identification of novel diagnostic and prognostic biomarkers in cancers using circulating tumour DNA in plasma and by means of Liquid Biopsy. She generated data sets in vitro with high-throughput sequencing, proteomics, and single cell analysis, while in silico she has specialized in mathematical modelling and data mining to generate testable hypotheses using high-throughput datasets. During her academic career, she won several prestigious fellowships, the last one in 2011, the Miguel Servet (FIS) fellowship given for one only young scientists in the Hospital Carlos III (Madrid, Spain) by the FIS Foundation. She joined the BIU Faculty of Medicine in Galilee as an independent PI (tenure-track Assistant Professor/Senior Lecturer) in October 2014.





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