Dr. Nissan Yissachar

Intestinal neuro-immune-microbiome cross-talks, in health and disease

The Mina and Everard Goodman Faculty of Life Sciences

Dr. Nissan Yissachar joined the Faculty of Life Sciences at Bar-Ilan University in 2017 following two post-doctoral fellowships, the first at the Weizmann Institute of Science and the second at Harvard Medical School. His lab at BIU investigate the interactions between the intestinal immune system, the enteric nervous system and the gut microbiota, in health and disease, aiming to develop a microbiome-based, personalized therapy for human inflammatory diseases.  

To study these complex neuro-immune-microbiome interactions in the lab, Dr. Yissachar developed a novel organ culture system for the mouse intestine. This unique approach led him to discover that enteric neurons mediate specific immunological effects of the human gut microbiome. In the future, these investigations may result in new therapeutic approaches to autoimmune diseases (such as type-1 diabetes and rheumatoid arthritis), chronic inflammatory diseases (such as crohn’s disease and ulcerative colitis) and cancer.








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