The Mina and Everard Goodman Faculty of Life Sciences
Prof. Sol Efroni is a former research fellow at the National Institutes of Health (Bethesda, MD). He joined the Mina & Everard Goodman Faculty of Life Sciences as a Senior Lecturer in 2009. Since then, the Efroni Systems Biomedicine Lab focuses on the genomics of tumors and the genomics of the immune system, using high-throughput methods, network biology and machine learning.
Since T cells and B cells have the unique ability to change their own genome to get better at what they do, T cells are often different from one another in their ability to “see”. Their combined perspective makes up the Immunological Repertoire, which is fundamentally different between individuals. Recent progress in the ability to sequence genomes, and progress with computational tools, now allows us to observe the T-cell repertoire in different patients. We build on these tools to associate diseases, their treatments, and their detection, with the T cell repertoire.
Building on the recent, and ever-growing, flood in genomics data, we in the Systems Biomedicine lab also develop tools to use pathway and network knowledge to discover hidden properties of cell regulation out of high-throughput data. We have been using pathway knowledge on top of gene and protein information to perform diagnosis and prognosis of samples from cancer patients and have shown the advantage in using such approach in multiple papers (all of them appear in the “Publications” section in this website). Often, we are able to highlight the pathways most critical to make diagnosis (or prognosis). We follow up on these findings in wet-lab experimentation to learn more about the mechanisms of these critical pathways.
Prof. Efroni received his B.Sc. in Physics from Tel-Aviv University, his M.A. in Cognitive Sciences from The Hebrew University and his Ph.D. in Immunology and in Computer Science from The Weizmann Institute.