The Azrieli Faculty of Medicine
Our team, led by Prof. Tzipora Falik-Zaccai, searches for genes responsible for rare genetic disorders and investigates the function and biological pathway of the related protein. We combine our expertise in medical genetics and the working environment of the unique populations of the Galilee with the power of advanced genetic tools to identify genes and variants causing rare disorders. Our goal is to address and achieve a major impact on personalized medicine for individuals and communities belonging to a founder ancestor. Novel genes we discover and their related phenotype shed light on novel proteins and pathways which are crucial for healthy life. These patient-based discoveries broaden our understanding of proteins that become the target of personalized drug development for rare but also common disorders. Of particular interest are phenotypes of seizures, early onset dementia, N-glycanase deficiency, DNA repair disorders and cardiomyopathies. Our group efforts led to the recent identification of two novel genes, one involved in a novel cardio-cutaneous syndrome and another that causes a unique type of progressive leukoencephalopathy. Our work provides the option for personalized medicine to individuals from different ethnic groups in Israel. Patients benefit immediately from our group's research, which is used to develop new diagnostic tools for their families and communities, together with new biological and/or pharmaceutical insights.
Prof. Tzipora Falik-Zaccai received her MD cum laude from the Technion and is board certified in pediatrics (Israel) and medical genetics (Israel, USA). She is currently the director of the Institute of Human Genetics, Galilee Medical Center in Nahariya, and head of the Department of Genetics and the MD PhD program in the Azrieli School of Medicine, Bar Ilan University, Safed. The partnership of Prof. Falik-Zaccai’s institute with the laboratories at the Azrieli faculty of Medicine offers a unique translational medicine environment for addressing personalized medicine in a range of genetic disorders.