Prof. Uri Nir

Stratifying cancer patients according to their potential response to anti-metabolic drugs

The Mina and Everard Goodman Faculty of Life-Sciences 


Prof. Uri Nir leads the "Cancer and Inflammatory diseases" research lab in the Faculty of Life-Sciences at Bar-Ilan University, Israel. Between the years 2010-2014 Prof. Nir served as the dean of the Faculty. Nir gained his PhD degree from the Weizmann Institute of Sciences in Israel. He then went for a post-doctoral training in the "Hormone-Research Institute" at the University of California San-Francisco, CA., USA. Since 1988 Prof. Nir is a faculty member in the Faculty of Life-Sciences at Bar-Ilan University. The main research interest of the Nir's group is: Molecular biology of malignant processes and diseases and development of new anti-cancer compounds. These two disciplines are combined by us in order to identify tumor associated genetic  susceptibility markers and factors which would stratify cancer patients according to their potential responsiveness to new anti-cancer drugs which selectively target the energy generation systems of cancer cells. This personalized-medicine approach should enable the rational selection of cancer patients for being treated with our newly developed anti-cancer compound-E260. This compound selectively targets the reprogrammed energy-generation power stations (mitochondria) of cancer cells, thereby leading to an energy crisis and necrotic death of the treated tumors.     





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